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Our new paper demonstrating that Rab12 activates LRRK2 by endorsing its localization to broken lysosomes is currently out in eLife! This work identifies…
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When older rats were dealt with which has a serine protease inhibitor for just two months, enzyme leakage and collagen damage have been drastically lowered, supplying a potential therapeutic method. Implications: These conclusions imply that dietary behaviors, which include meal frequency and caloric consumption, could impact the speed of enzymatic leakage and connected tissue injury, shedding a lightweight on new avenues for therapeutic and Life style interventions to preserve tissue integrity and metabolic health. Learn more by studying our whole website as well as paper alone listed here:
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3Helix, Inc. Could Digestive Enzymes Lead to Growing old? UCSD researchers have hypothesized a mechanism of growing old named “autodigestion”- exactly where digestive enzymes like trypsin, Generally confined into the smaller intestine, leak into peripheral organs as we age. This leakage triggers major tissue destruction, resulting in increased amounts of collagen damage inside organs linking this autodigestion to aging.
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